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I request access to data collected by the “Estudo de correlação de ressonância magnética com variantes genéticas em octagenários saudáveis” (OCTAGENE) for the purpose of scientific investigation or teaching and agree to the following terms.

1. I will receive access to de-identified data and will not attempt to establish the identity of, or attempt to contact any of the OCTAGENE subjects.

2. I will not attempt to make direct contact with OCTAGENE PIs or staff at sites concerning the specific results of individual subjects.

3. I will not further disclose these data beyond the uses outlined in this agreement and my data use application and understand that redistribution of data in any manner is prohibited.

4. I will require anyone on my team who utilizes these data, or anyone with whom I share these data to comply with this data use agreement.

5. I will accurately provide the requested information for persons who will use these data and the analyses that are planned using these data.

6. I will respond promptly and accurately to requests to update this information made by the OCTAGENE study.

7. I will comply with any rules and regulations imposed by my institution and its institutional review board in requesting these data. If I publish abstracts using data from OCTAGENE, I agree to the following:

8. I will cite OCTAGENE as the source of data and the OCTAGENE funding sources in the abstract as space allows.

9. Acknowledgement of OCTAGENE will not be cited in the authorship line of the abstract. If I publish manuscripts using data from OCTAGENE, I agree to the following:

10. On the by-line of the manuscript, after the named authors, I will include the phrase “for the OCTAGENE*” with the asterisk referring to the following statement and list of names:

*Data used in preparation of this article were obtained from the OCTAGENE database. As such, the investigators within the OCTAGENE contributed to the design and implementation of OCTAGENE and/or provided data but did not participate in analysis or writing of this report. A complete listing of OCTAGENE investigators can be found at:

11. I will include language similar to the following in the methods section of my manuscripts in order to accurately acknowledge data gathering by the OCTAGENE personnel. Depending upon the length and focus of the article, it may be appropriate to include more or less than the example below, however inclusion of some variation of the language shown below is mandatory.

Data used in the preparation of this article were obtained from the OCTAGENE. The OCTAGENE was launched in 2010. The primary goal of OCTAGENE has been to test whether magnetic resonance imaging (MRI), other biological markers, and clinical and neuropsychological assessment can be combined to measure assess the health status of old-age individuals living in the city of São Paulo and whether genetic variables would be associated with imaging endophenotypes. For up-to-date information, see

12. I will acknowledge funding by the OCTAGENE in the support acknowledgement section of the manuscript using language similar to the following:

Data collection and sharing for this project was funded by the OCTAGENE project - OCTAGENE is funded by the Instituto Israelita de Ensino e Pesquisa Albert Einstein and Weizmann Institute of Science, and through generous contributions from the following: partnership: SABE Project and Genome Project. The grantee organization is the Brain Institute at Albert Einstein Hospital, Sao Paulo.

13. I will submit all manuscripts to the OCTAGENE Data Sharing and Publications Committee (ODSPC) prior to submitting to a journal. This review will not be a scientific review, but is intended to ensure that items 7-12 above are correctly implemented. The DPC will maintain confidentiality of the manuscript and will complete its review within 2 weeks. The manuscripts should be sent to

14. I will ensure that Investigators who utilize OCTAGENE data use appropriate administrative, physical and technical safeguards to prevent use or disclosure of the data other than as provided for by this Agreement.

15. I will report any use or disclosure of the data not provided for by this Agreement of which I become aware within 15 days of becoming aware of such use or disclosure.